反应详情

To a flask containing 13A (1 g) and dichloro[1,3-bis (diphenylphosphino)propane]nickle(II) (15 mg, prepared as in Kumada et al., Org. Syn. Coll. Vol. VI, p 407) is added THF (11 ml) and octyl magnesium bromide (2M, 2.74 ml). The solution is refluxed for 16 hrs, then poured into water and extracted three times with ethyl acetate. The combined organic layers are washed with brine and dried over sodium sulfate, and the solvent is removed in vacuo.

1. temperatureThe solution is refluxed for 16 hrs
2. extractionextracted three times with ethyl acetate
3. washThe combined organic layers are washed with brine
4. dry with materialdried over sodium sulfate
5. customthe solvent is removed in vacuo