2,4-Diamino-6-chloropyrimidine → HCID 18946293, compound

HRID 1768963Notes

Reaction equation

HRID 1768963 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([NH2:9])[N:3]=1.[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>ClC1C=CC=CC=1>[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:6]2[CH:5]=[C:4]([NH2:9])[N:3]=[C:2]([NH2:1])[N:7]=2)[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

Participants

4

Reactant 2

HCID 674322,4-Diamino-6-chloropyrimidineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 18946293HCID 18946293, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of 2,6-diamino-4-chloropyrimidine (2.88 g, 20 mmol) and 1- (tert-butoxycarbonyl)piperazine (5.6 g, 30 mmol) in chlorobenzene (30 ml) was stirred under reflux for 3 hours. After cooling the formed precipitate was collected and stirred with aqueous 1N NaOH (63 ml) at room temperature for 15 minutes. The solids were collected, washed with water and dried, yield: 90.4%, mp. 176°-179° C.

Workup

  1. temperatureunder reflux for 3 hours
  2. temperatureAfter cooling the formed precipitate
  3. customwas collected
  4. stirringstirred with aqueous 1N NaOH (63 ml) at room temperature for 15 minutes
  5. customThe solids were collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-4f2c63873b85405d8b0940922e6b8f9b
Source dataset
uspto-grants-1995_01
Patent number
US05380724

Reaction notes

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