2,4-Diamino-6-chloropyrimidine → HCID 18946293, compound

Participants

Reaction Steps

A mixture of 2,6-diamino-4-chloropyrimidine (2.88 g, 20 mmol) and 1- (tert-butoxycarbonyl)piperazine (5.6 g, 30 mmol) in chlorobenzene (30 ml) was stirred under reflux for 3 hours. After cooling the formed precipitate was collected and stirred with aqueous 1N NaOH (63 ml) at room temperature for 15 minutes. The solids were collected, washed with water and dried, yield: 90.4%, mp. 176°-179° C.

Provenance & Evidence