Benzhydrylpiperazine → HCID 20098363, compound

HRID 1768995Notes

Reaction equation

[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:24]=[CH:23][CH:22]=[CH:21][C:7]=1[C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][N:15]2[CH3:20])=[O:9].[C:25]1([CH:31]([N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[OH:1][CH:2]([CH2:3][N:41]1[CH2:42][CH2:43][N:38]([CH:31]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:39][CH2:40]1)[CH2:4][O:5][C:6]1[CH:24]=[CH:23][CH:22]=[CH:21][C:7]=1[C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][N:15]2[CH3:20])=[O:9]

Participants

Reactant 2

HCID 70048Benzhydrylpiperazine

HCID 15611141HCID 15611141, compound

Product 1

HCID 20098363HCID 20098363, compound

Procedure

Using the procedure of Example 28, of Step C, 4 g of 2-[(2-oxiranyl)methoxy]-N-(1-methyl-1H-indol-4-yl)benzamide of Example 34 and and 6.3 g of diphenylmethylpiperazine were reacted to obtain 5.95 of 2-[2-hydroxy-3-[4-(diphenylmethyl)-1-piperazinyl]propoxy]-N-(1-methyl-1H-indol-4-yl)benzamide and then 4.9 g of its hydrochloride melting at 196° C. after crystallization from ethanol.

Sources & evidence

ORD record: ord-3f252f9ee69e4f9a867886c2301a8cbe
Source dataset: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05380722

Reaction notes

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