反应详情

A mixture of 3.5 g of the product of Step C, 150 ml of acetone, 1.5 g of potassium carbonate and 9 ml of epibromohydrin was refluxed for 2 hours and after the addition of another 9 ml of epibromohydrin, the mixture was refluxed for 20 hours and was filtered. The filtrate was washed with acetone and evaporated to dryness under reduced pressure at 50° C. The residue was taken up in ether and was filtered. The product was dried at 80° C. to obtain 3.4 g of 5-acetylamino-2-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide melting at 230° C.

1. temperaturewas refluxed for 2 hours
2. temperaturethe mixture was refluxed for 20 hours
3. filtrationwas filtered
4. washThe filtrate was washed with acetone
5. customevaporated to dryness under reduced pressure at 50° C
6. filtrationwas filtered
7. customThe product was dried at 80° C.