Water → HCID 15764683, compound

HRID 1769044Notes

Reaction equation

HRID 1769044 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH:6]=[C:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]2([CH2:14][N:15]2[CH:19]=[N:18][CH:17]=[N:16]2)[OH:13])=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:30])C=1.O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]2[C:7]3([CH2:12][CH2:11][CH2:10][CH2:9][C:8]3([CH2:14][N:15]3[CH:19]=[N:18][CH:17]=[N:16]3)[OH:13])[O:30]2)=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 70297m-Chloroperbenzoic acidHCID 54366591HCID 54366591, compound

Product 1

HCID 15764683HCID 15764683, compoundYield 63.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 9 g of 2-(4-chlorobenzylidene)-1-(1,2,4-triazol-1-ylmethyl)cyclohexan-1-ol and 14.8 g of m-chloroperbenzoic acid in 50 ml of dichloromethane is stirred for 3 h at room temperature. 200 ml of water are then added and extracted with 3×100 ml of dichloromethane. The organic phase is washed with a potassium carbonate solution. The organic phase is dried over sodium sulphate and evaporated. The residue is crystallised from diisopropyl ether to produce 6 g of white solid (M.p.=150.5° C.)

Workup

  1. extractionextracted with 3×100 ml of dichloromethane
  2. washThe organic phase is washed with a potassium carbonate solution
  3. dry with materialThe organic phase is dried over sodium sulphate
  4. customevaporated
  5. customThe residue is crystallised from diisopropyl ether

Sources & evidence

ORD record
ord-5b86bae4719743449211eb85913119fe
Source dataset
uspto-grants-1995_01
Patent number
US05380741

Reaction notes

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