Tetrahydrofuran → 1,1-Diethoxy-2-methylprop-1-ene

HRID 1769066Notes

Reaction equation

HRID 1769066 reaction equation
C[C:2](C)([O-:4])[CH3:3].[K+].CCC[CH2:10][CH2:11][CH3:12].C1[CH2:17][O:16][CH2:15][CH2:14]1>>[CH2:15]([O:16][C:17]([O:4][CH2:2][CH3:3])=[C:11]([CH3:10])[CH3:12])[CH3:14]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 23665647Potassium tert-butoxide

Product 1

HCID 152051731,1-Diethoxy-2-methylprop-1-ene

Procedure

To a solution of the compound of preparation 41(b) (2.3 g, 0.02 mol) in THF (50 mL) was added potassium t-butoxide (2.3 g, 0.02 mol). The mixture was stirred at room temperature for 1 hour, then hexane (20 mL) was added. The mixture was filtered through celite, the filtrate was concentrated in vacuo, and the residue was distilled at 50 mmHg to afford 2.1 g of 1,1-diethoxy-2,2-dimethylethylene (Formula V: R3 =R4 =CH3 ; R5 =R6 =OC2H5).

Workup

  1. filtrationThe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. distillationthe residue was distilled at 50 mmHg

Sources & evidence

ORD record
ord-21105299eef74ce3a687f82758acec9c
Source dataset
uspto-grants-1995_01
Patent number
US05380729

Reaction notes

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