Hydrogen Bromide → HCID 18947045, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6.98 g (0.02 mol) of 1,3-dichloro-5-tosyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole and 50 ml of a 33% solution of hydrobromic acid in acetic acid, placed in a sealed tube, is heated at 90° C. in a water bath for 90 min. The reaction mixture is then cooled, and the precipitate formed is filtered off, washed twice with diethyl ether and dried. There are obtained 4.75 g of compound in the hydrobromide form (Melting point >270° C.). Treatment of this salt with sodium carbonate in water produces 3.35 g of base. Melting point: 80.5°-82.5° C.

Provenance & Evidence