Hydrogen Bromide → HCID 18947045, compound

HRID 1769082Notes

Reaction equation

HRID 1769082 reaction equation
[Cl:1][C:2]1[S:3][C:4]([Cl:20])=[C:5]2[CH2:9][N:8](S(C3C=CC(C)=CC=3)(=O)=O)[CH2:7][C:6]=12.Br>C(O)(=O)C>[Cl:1][C:2]1[S:3][C:4]([Cl:20])=[C:5]2[CH2:9][NH:8][CH2:7][C:6]=12

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 18947062HCID 18947062, compound

Product 1

HCID 18947045HCID 18947045, compoundYield 122.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 6.98 g (0.02 mol) of 1,3-dichloro-5-tosyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole and 50 ml of a 33% solution of hydrobromic acid in acetic acid, placed in a sealed tube, is heated at 90° C. in a water bath for 90 min. The reaction mixture is then cooled, and the precipitate formed is filtered off, washed twice with diethyl ether and dried. There are obtained 4.75 g of compound in the hydrobromide form (Melting point >270° C.). Treatment of this salt with sodium carbonate in water produces 3.35 g of base. Melting point: 80.5°-82.5° C.

Workup

  1. customplaced in a sealed tube
  2. temperatureThe reaction mixture is then cooled
  3. customthe precipitate formed
  4. filtrationis filtered off
  5. washwashed twice with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-95d2388e00e14987a1dfb642054ffe0b
Source dataset
uspto-grants-1995_01
Patent number
US05380742

Reaction notes

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