Trifluoroacetic acid → HCID 18947029, compound

HRID 1769084Notes

Reaction equation

HRID 1769084 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Br:8][C:9]1[S:10][C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:12]2[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][C:13]=12>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Br:8][C:9]1[S:10][C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[C:12]2[CH2:16][NH:15][CH2:14][C:13]=12

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18947034HCID 18947034, compound

Product 1

HCID 18947029HCID 18947029, compoundYield 91%

Procedure

1.5 ml of trifluoroacetic acid are added to 0.98 g (1.32 mmol) of 1-bromo-3-phenyl-5-(1,1-dimethylethoxy)carbonyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole. After 10 minutes at room temperature, the solvent is evaporated to dryness. 5 ml of toluene are added and the mixture is evaporated to dryness. The residue is triturated with 5 ml of diethyl ether, filtered and dried. There is obtained 0.95 g of a yellowish solid. Yield 91%.

Workup

  1. customthe solvent is evaporated to dryness
  2. addition5 ml of toluene are added
  3. customthe mixture is evaporated to dryness
  4. customThe residue is triturated with 5 ml of diethyl ether
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-187557d05e674f2f900428721bb565e3
Source dataset
uspto-grants-1995_01
Patent number
US05380742

Reaction notes

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