反应详情

5 g of calcium chloride and 0.17 ml (3 mmol) of acetic acid are added to a solution of 0.81 g (2.86 mmol) of 1-(2-hydroxy-2-propyl)-5-(1,1-dimethyl-ethoxy) carbonyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole in 60 ml of chloroform. The mixture is heated at reflux for 24 hours, filtered, washed with a 5% sodium bicarbonate solution, then dried over sodium sulphate and evaporated to dryness. 0.78 g of an oily product is obtained.

1. temperatureThe mixture is heated
2. temperatureat reflux for 24 hours
3. filtrationfiltered
4. washwashed with a 5% sodium bicarbonate solution
5. dry with materialdried over sodium sulphate
6. customevaporated to dryness