Hydrochloric Acid → HCID 178419496, compound

Participants

Reaction Steps

A suspension of 0.7 g (1.15 mmol) of 1,3-dibromo-5[(1-triphenylmethyl-1H-imidazol-4-yl) methyl]-5,6-dihydro-4H-thieno[3,4-c]pyrrole in 14 ml of 2M hydrochloric acid is heated at reflux for 1 hour. The precipitate formed is filtered and washed with water. The combined aqueous phases are washed with ethyl acetate and then evaporated to dryness to provide 0.45 g of a chestnut-brown solid which is crystallized from isopropanol. 0.082 g of a cream solid is obtained. Yield 17%. Melting point: 221° C. (with decomposition).

Provenance & Evidence