Hydrochloric Acid → HCID 178419496, compound

HRID 1769100Notes

Reaction equation

HRID 1769100 reaction equation
[Br:1][C:2]1[S:3][C:4]([Br:35])=[C:5]2[CH2:9][N:8]([CH2:10][C:11]3[N:12]=[CH:13][N:14](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:15]=3)[CH2:7][C:6]=12.[ClH:36]>>[ClH:36].[ClH:36].[Br:1][C:2]1[S:3][C:4]([Br:35])=[C:5]2[CH2:9][N:8]([CH2:10][C:11]3[N:12]=[CH:13][NH:14][CH:15]=3)[CH2:7][C:6]=12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54141264HCID 54141264, compound

Product 1

HCID 178419496HCID 178419496, compound

Procedure

A suspension of 0.7 g (1.15 mmol) of 1,3-dibromo-5[(1-triphenylmethyl-1H-imidazol-4-yl) methyl]-5,6-dihydro-4H-thieno[3,4-c]pyrrole in 14 ml of 2M hydrochloric acid is heated at reflux for 1 hour. The precipitate formed is filtered and washed with water. The combined aqueous phases are washed with ethyl acetate and then evaporated to dryness to provide 0.45 g of a chestnut-brown solid which is crystallized from isopropanol. 0.082 g of a cream solid is obtained. Yield 17%. Melting point: 221° C. (with decomposition).

Workup

  1. temperatureis heated
  2. temperatureat reflux for 1 hour
  3. customThe precipitate formed
  4. filtrationis filtered
  5. washwashed with water
  6. washThe combined aqueous phases are washed with ethyl acetate
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-5fc4f64ea266428b849157f0e54c4427
Source dataset
uspto-grants-1995_01
Patent number
US05380742

Reaction notes

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