Hydrochloric Acid → HCID 178478562, compound

Participants

Reaction Steps

0.14 g (0.3 mmol) of 5-[(1-triphenylmethyl-1H-imidazol-4-yl)methyl]-5,6-dihydro-4H -thieno-[3,4-c]pyrrole is dissolved in 1 ml of ethanol, 1.5 ml of 2M hydrochloric acid is then added and the mixture is heated at reflux for 1 hour. The precipitate formed is filtered and the filtrate is washed with twice 1 ml of ethyl acetate and then evaporated to dryness. The residue is dissolved in 2 ml of methanol and decoloured with active charcoal and then recrystallized from isopropanol. There is obtained 0.075 g of cream-white solid in a yield of 86%. Melting point: 260° C.

Provenance & Evidence