Hydrochloric Acid → HCID 178478562, compound

HRID 1769101Notes

Reaction equation

HRID 1769101 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][N:14]3[CH2:18][C:17]4=[CH:19][S:20][CH:21]=[C:16]4[CH2:15]3)[N:10]=[CH:9]2)C=CC=CC=1.[ClH:34]>C(O)C>[ClH:34].[ClH:34].[NH:8]1[CH:12]=[C:11]([CH2:13][N:14]2[CH2:15][C:16]3=[CH:21][S:20][CH:19]=[C:17]3[CH2:18]2)[N:10]=[CH:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15228195HCID 15228195, compound

Product 1

HCID 178478562HCID 178478562, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.14 g (0.3 mmol) of 5-[(1-triphenylmethyl-1H-imidazol-4-yl)methyl]-5,6-dihydro-4H -thieno-[3,4-c]pyrrole is dissolved in 1 ml of ethanol, 1.5 ml of 2M hydrochloric acid is then added and the mixture is heated at reflux for 1 hour. The precipitate formed is filtered and the filtrate is washed with twice 1 ml of ethyl acetate and then evaporated to dryness. The residue is dissolved in 2 ml of methanol and decoloured with active charcoal and then recrystallized from isopropanol. There is obtained 0.075 g of cream-white solid in a yield of 86%. Melting point: 260° C.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 1 hour
  3. customThe precipitate formed
  4. filtrationis filtered
  5. washthe filtrate is washed with twice 1 ml of ethyl acetate
  6. customevaporated to dryness
  7. dissolutionThe residue is dissolved in 2 ml of methanol
  8. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-94bc231a9dc542f39261170f230105cc
Source dataset
uspto-grants-1995_01
Patent number
US05380742

Reaction notes

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