反应详情

1.5 g of 2-amino-4-(2,4-dimethoxyphenyl)-5-ethoxycarbonylmethylthiazole, 1 g of 1-acetylindole-2carboxylic acid, 0.7 ml of triethylamine and 2.39 g of BOP are dissolved in 15 ml of dichloromethane. The reaction mixture is stirred overnight at room temperature and then concentrated under vacuum. The residue is taken up in ethyl acetate and the solution is successively washed with a buffer solution, pH=2, with a 5% solution of NaHCO3 and with water, and then the organic phase is dried over MgSO4 and concentrated under vacuum. The residue is purified by chromatography on a silica gel, eluent: dichloromethane/ethyl acetate 100/2.5 (v/v).

1. concentrationconcentrated under vacuum
2. washthe solution is successively washed with a buffer solution, pH=2, with a 5% solution of NaHCO3 and with water
3. dry with materialthe organic phase is dried over MgSO4
4. concentrationconcentrated under vacuum
5. customThe residue is purified by chromatography on a silica gel, eluent