Sodium Carbonate → HCID 18946568, compound

HRID 1769103Notes

Reaction equation

HRID 1769103 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]1[C:13]([NH:15][C:16]1[S:17][C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:20]=1)=[O:14])(=O)C.C([O-])([O-])=O.[Na+].[Na+]>C(O)C>[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]1[C:13]([NH:15][C:16]1[S:17][C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:19]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:20]=1)=[O:14]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 19023639HCID 19023639, compound

Product 1

HCID 18946568HCID 18946568, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By carrying out the procedure according to Example 10 which is described above, the compound 2-[(1-acetyl-2-indolyl ) carbonylamino]-4-phenyl-5-ethoxycarbonylthiazole (1.5 g) is prepared and dissolved in 100 ml of ethanol in the presence of 0.6 g of Na2CO3. The mixture is stirred at room temperature for 48 hours and then concentrated under vacuum. The residue is triturated in water and then in a minimum amount of dichloromethane, filtered and dried.

Workup

  1. customis prepared
  2. concentrationconcentrated under vacuum
  3. customThe residue is triturated in water
  4. filtrationin a minimum amount of dichloromethane, filtered
  5. customdried

Sources & evidence

ORD record
ord-41139a09542f4bcd86e39e113572b181
Source dataset
uspto-grants-1995_01
Patent number
US05380736

Reaction notes

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