Sodium Hydroxide → HCID 15225070, compound

HRID 1769153Notes

Reaction equation

HRID 1769153 reaction equation
[CH3:1][N:2]([CH3:16])[C:3]1([C:12](OC)=[O:13])[C:8]2[CH:9]=[CH:10][S:11][C:7]=2[CH2:6][CH2:5][CH2:4]1.[H-].[Li+].[Al+3].[H-].[H-].[H-].[OH-].[Na+]>CCOCC>[CH3:1][N:2]([CH3:16])[C:3]1([CH2:12][OH:13])[C:8]2[CH:9]=[CH:10][S:11][C:7]=2[CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 18947229HCID 18947229, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 15225070HCID 15225070, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

65 ml of ether solution containing 7.77 g of 4-dimethylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene obtained in Step 2 was added to an ice-cooled suspension of aluminum lithium hydride (1.23 g) in ether, then stirred for 20 minutes at room temperature. The reaction mixture was added with 5% NaOH solution, filtrated to remove the insoluble matters, followed by drying the organic phase.

Workup

  1. temperaturecooled
  2. filtrationfiltrated
  3. customto remove the insoluble matters
  4. customby drying the organic phase

Sources & evidence

ORD record
ord-05bc694dc2dd46c3915f6150d0507aac
Source dataset
uspto-grants-1995_01
Patent number
US05380748

Reaction notes

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