反应详情

A solution of 1-amino-2-(2,6-dichloro-4-trifluoromethylbenzylideneamino)-1,2-dicyanoethylene (3.3 g, 0.01 mol) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (3.3 g, 0.01 mol) in acetonitrile (75 ml) was stirred at reflux for 48 hours. Evaporation of the solvent yielded a brown solid which was continuously extracted with boiling toluene. The solution was evaporated under reduced pressure and the red-brown residue was dissolved in a mixture of ethyl acetate and dichloromethane (1:10) and filtered through silica. Evaporation of the liltrate gave a brown solid which was triturated with hexane and the solid was removed by filtration to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-dicyanoimidazole (1.4 g) as a light brown solid, m.p. 194°-195° C.

1. temperatureat reflux for 48 hours
2. customEvaporation of the solvent
3. customyielded a brown solid which
4. extractionwas continuously extracted with boiling toluene
5. customThe solution was evaporated under reduced pressure
6. dissolutionthe red-brown residue was dissolved in a mixture of ethyl acetate and dichloromethane (1:10)
7. filtrationfiltered through silica
8. customEvaporation of the
9. customliltrate gave a brown solid which
10. customwas triturated with hexane
11. customthe solid was removed by filtration