Quiflapon → 3-[n-(4-Chlorobenzyl)-3-(1,1-dimethylethyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Quiflapon	HCID 60923	—
Reactant	Methyl 3-[N-(4-chlorobenzyl)-3-(1,1-dimethylethyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate	HCID 18947566	—
Product	3-[n-(4-Chlorobenzyl)-3-(1,1-dimethylethyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid	HCID 18947537	—

Reaction Steps

The title compound was prepared according to the conditions described in Step B of Example 1, but substituting the ester from Step B for the ester of Example 1. The title compound was recrystallized from EtOAc-EtOH; m.p. 201°-202° C. Anal. Calc. C 73.57; H 6.36; N 5.05 Found C 73.75; H 6.37; N 5.03.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05380850
Source dataset	uspto-grants-1995_01
ORD ID	ord-4ef98ad75b2d40ae910dd6dfb656912f
Source note	uspto-grants-1995_01