HRID1769380

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7679

Benzeneacetyl chloride

C8H7ClO

HCID5360545

Sodium

结构：COC(=O)C(C)(C)Cc1cc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1

HCID9892642

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Cc1c(C(=O)Cc2ccccc2)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1)C(=O)O

HCID21661036

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the conditions described in Step B and Step C of Example 47, from methyl 3-[N-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy) indol-2-yl]-2,2-dimethylpropanoate (prepared in Step A of Example 47), but using phenylacetyl chloride in place of trimethylacetyl chloride in Step B. Anal. C, H, N for sodium salt·1H2O Calc. C 69.46; H 5.22; N 4.26 Found C 69.71; H 5.25; N 4.11.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-368ea2992f84455e9fcb26c6294efc10
来源数据集: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05380850
来源说明: uspto-grants-1995_01

反应 SMILES

[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH2:17][C:18]4[CH:27]=[CH:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)=[CH:13][CH:14]=3)[CH:9]=[C:8]2[CH2:28][C:29]([CH3:35])([CH3:34])[C:30]([O:32]C)=[O:31])=[CH:4][CH:3]=1.[C:38]1([CH2:44][C:45](Cl)=[O:46])[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1.[Na]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH2:17][C:18]4[CH:27]=[CH:26][C:25]5[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=5)[N:19]=4)=[CH:13][CH:14]=3)[C:9]([C:45](=[O:46])[CH2:44][C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)=[C:8]2[CH2:28][C:29]([CH3:35])([CH3:34])[C:30]([OH:32])=[O:31])=[CH:36][CH:37]=1