Methylamine → HCID 9795805, compound

HRID 1769415Notes

Reaction equation

HRID 1769415 reaction equation
C[O:2][C:3](=O)/[C:4](/[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)=[N:5]/[OH:6].[CH3:22][NH2:23]>CO>[OH:6]/[N:5]=[C:4](\[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)/[C:3]([NH:23][CH3:22])=[O:2]

Participants

4

Reactant 2

HCID 6329Methylamine2×HCID 88361076HCID 88361076, compound

Product 1

HCID 9795805HCID 9795805, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

E-α-hydroxyimino-2-(4-methylphenoxy)phenylacetic acid methyl ester (1.00 g, 0.0035 mole) was dissolved in methanol (7 ml) and 40% methylamine solution in methanol (0.54 g, 0.007 mole) was added to the mixture, which was refluxed for 70 minutes. A 40% methylamine solution in methanol (1.36 g, 0.0175 mole) was further added to the mixture, which was refluxed for 3 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to give E-2-hydroxyimino-N-methyl-2-[2-(4-methylphenoxy)phenyl]acetamide (1.00 g, yield: 100.0%) as an amorphous.

Workup

  1. temperaturewas refluxed for 70 minutes
  2. temperaturewas refluxed for 3 hours
  3. customAfter completion of the reaction
  4. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cb7f08171f95463a80104a46366e08c5
Source dataset
uspto-grants-1995_01
Patent number
US05380913

Reaction notes

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