Pyrrolidine → HCID 22418784, compound

HRID 1769449Notes

Reaction equation

HRID 1769449 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[C:6](Cl)[N:5]=1)[CH3:2].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[C:6]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 22418728HCID 22418728, compound

Product 1

HCID 22418784HCID 22418784, compound

Procedure

A solution of 2-diethylamino-4-piperazino-6-chloropyrimidine (4.10 g) in pyrrolidine (4.10 g) is heated at 100° for 12 h. The mixture is concentrated and the residue is partitioned between aqueous sodium bicarbonate and methylene chloride. The phases are separated and the organic phase is dried and concentrated to give the title compound, NMR (CDCl3) 1.15, 1.90, 2.90, 3.45, 3.70 and 4.75 δ.

Workup

  1. concentrationThe mixture is concentrated
  2. customthe residue is partitioned between aqueous sodium bicarbonate and methylene chloride
  3. customThe phases are separated
  4. customthe organic phase is dried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-bbec7ce9242c4d1a8ddaae6d7440c69e
Source dataset
uspto-grants-1995_01
Patent number
US05380839

Reaction notes

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