Pyrrolidine → HCID 22418784, compound

HRID 1769474Notes

Reaction equation

HRID 1769474 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[C:6](Cl)[N:5]=1)[CH3:2].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[C:6]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 22418728HCID 22418728, compound

Product 1

HCID 22418784HCID 22418784, compound

Procedure

A solution of 2-diethylamino-4-piperazino-6-chloropyrimidine (4.10 g) in pyrrolidine (4.10 g) is heated at 100° for 12 h. The mixture is concentrated and the residue is partitioned between aqueous sodium bicarbonate and methylene chloride. The phases are separated and the organic phase is dried and concentrated to give the title compound, NMR (CDCl3) 1.15, 1.90, 2.90, 3.45, 3.70 and 4.75 δ.

Workup

  1. concentrationThe mixture is concentrated
  2. customthe residue is partitioned between aqueous sodium bicarbonate and methylene chloride
  3. customThe phases are separated
  4. customthe organic phase is dried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f111f355211a4a5baf46b358d5f6815e
Source dataset
uspto-grants-1995_01
Patent number
US05380840

Reaction notes

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