Hydrazine → 1-Formyl 4-[5,6-bis(2-pyridinyl)-1,2,4-triazin-3-yl]-piperazine

HRID 1769519Notes

Reaction equation

HRID 1769519 reaction equation
I.[CH:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10](=[NH:12])[NH2:11])[CH2:6][CH2:5]1)=[O:3].[O-]CC.[Na+].[NH2:17]N.[CH:19]1[CH:24]=[C:23]([C:25]([C:27]([C:29]2[N:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=O)=O)[N:22]=[CH:21][CH:20]=1>C(O)C>[CH:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[N:17][C:27]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][N:34]=3)=[C:25]([C:23]3[CH:24]=[CH:19][CH:20]=[CH:21][N:22]=3)[N:12]=2)[CH2:6][CH2:5]1)=[O:3]

Participants

6

Reactant 4

HCID 9321HydrazineHCID 68115Di-2-pyridylethanedioneHCID 2723922Sodium ethoxideHCID 130363664-Formyl-piperazinecarboximidamide hydroiodide

Product 1

HCID 224187591-Formyl 4-[5,6-bis(2-pyridinyl)-1,2,4-triazin-3-yl]-piperazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture of 4-formyl-piperazinecarboximidamide hydroiodide (prepared according to U.S. Pat. No. 4,351,832) in ethanol (4 ml) and ethanolic sodium ethoxide (1.4N, 6.8 ml) is stirred for 15 min and then anhydrous hydrazine (0.32 g) in ethanol (3 ml) is added. The mixture is stirred an additional 15 min, then 2,2'-pyridil (2.12 g) is added. The mixture is stirred for 12 hours at 25° and concentrated. The residue is chromatographed on silica gel eluting with a methylene chloride/methanol mixture. The appropriate fractions are pooled and concentrated to give 1-formyl 4-[5,6-bis(2-pyridinyl)-1,2,4-triazin-3-yl]-piperazine. Hydrolysis of the formamide in the usual way (PREPARATION A-14) gives the title compound.

Workup

  1. customprepared
  2. stirringThe mixture is stirred for 12 hours at 25°
  3. concentrationconcentrated
  4. customThe residue is chromatographed on silica gel eluting with a methylene chloride/methanol mixture
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-ac6ab1a62fc84af48382bfe4c7a3a14a
Source dataset
uspto-grants-1995_01
Patent number
US05380841

Reaction notes

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