HCID 57052782, compound → HCID 86748402, compound

HRID 1769576Notes

Reaction equation

HRID 1769576 reaction equation
[CH2:1]1[CH2:22][O:21][C:3]2([CH2:8][CH2:7][C:6]([C:9]3[CH:14]=[C:13]([F:15])[C:12]([C:16]([F:19])([F:18])[F:17])=[C:11]([F:20])[CH:10]=3)=[CH:5][CH2:4]2)[O:2]1.[H][H]>C(O)C.[Pd]>[CH2:22]1[CH2:1][O:2][C:3]2([CH2:4][CH2:5][CH:6]([C:9]3[CH:14]=[C:13]([F:15])[C:12]([C:16]([F:17])([F:18])[F:19])=[C:11]([F:20])[CH:10]=3)[CH2:7][CH2:8]2)[O:21]1

Participants

5

Reactant 2

HCID 57052782HCID 57052782, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86748402HCID 86748402, compoundYield 90.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1,1-Ethylenedioxy-4-(3',5'-difluoro-4'-trifluoromethylphenyl)-3-cyclohexene (17.3 g) was dissolved in ethanol (200 ml), followed by adding Pd/C (5%) (5 g), carrying out a catalytic reduction with stirring in a hydrogen gas atmosphere, filtering off the catalyst after completion of the reaction, and distilling off the organic layer under reduced pressure, to obtain 1,1-ethylenedioxy-4-(3',5'-difluoro-4'-trifluoromethylphenyl)cyclohexane (15.7 g).

Workup

  1. filtrationfiltering off the catalyst
  2. customafter completion of the reaction
  3. distillationdistilling off the organic layer under reduced pressure

Sources & evidence

ORD record
ord-05886c0c298b4ffdaea151de4e3c0915
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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