HCID 54188169, compound → HCID 54100496, compound

HRID 1769579Notes

Reaction equation

HRID 1769579 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]2[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[H][H]>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8]

Participants

5

Reactant 2

HCID 54188169HCID 54188169, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 54100496HCID 54100496, compoundYield 97.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(2'-(3",4",5"-Trifluorophenyl)ethenyl)cyclohexanone (71 g) was dissolved in ethanol (500 ml), followed by adding Pd/C (5%) (2.0 g), hydrogenating the compound in a hydrogen gas atmosphere with stirring till the hydrogen absorption was completed, filtering off the catalyst after completion of the reaction, and concentrating the solvent under reduced pressure, to obtain 4-(2'-(3",4",5"-trifluorophenyl)ethyl)cyclohexanone (70 g).

Workup

  1. filtrationfiltering off the catalyst
  2. customafter completion of the reaction
  3. concentrationconcentrating the solvent under reduced pressure

Sources & evidence

ORD record
ord-16b7281a90f04087b884076e186ab443
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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