HCID 67588708, compound → HCID 67588885, compound

HRID 1769583Notes

Reaction equation

HRID 1769583 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][O:12][C:13]([CH:15]=[C:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[H][H]>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][O:12][C:13]([CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])[CH:5]=[C:6]([F:9])[C:7]=1[F:8]

Participants

5

Reactant 2

HCID 67588708HCID 67588708, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67588885HCID 67588885, compoundYield 93.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(3',4',5'-Trifluorophenyl)ethoxycarbonylmethylenecyclohexane (18.3 g) was dissolved in ethanol (100 ml), followed by adding Pd/C (5%, 5 g), stirring the mixture, hydrogenating in a hydrogen gas atmosphere until completion of absorption of a hydrogen, filtering off the catalyst after completion of the reaction, and concentrating the solvent under reduced pressure, to obtain 4 -(3',4',5'-trifluorophenyl)ethoxycarbonylmethylcyclohexane (17.2 g).

Workup

  1. customuntil completion of absorption of a hydrogen
  2. filtrationfiltering off the catalyst
  3. customafter completion of the reaction
  4. concentrationconcentrating the solvent under reduced pressure

Sources & evidence

ORD record
ord-e9790a6240514306be9088fa8218b830
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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