HCID 86748406, compound → HCID 86748405, compound

HRID 1769586Notes

Reaction equation

HRID 1769586 reaction equation
[CH2:1]1[CH2:27][O:26][C:3]2([CH2:8][CH2:7][CH:6]=[CH:5][CH:4]2[CH2:9][CH2:10][CH:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[CH:18]=3)[CH2:13][CH2:12]2)[O:2]1.[H][H]>C(O)C.[Pd]>[CH2:27]1[CH2:1][O:2][C:3]2([CH2:8][CH2:7][CH2:6][CH2:5][CH:4]2[CH2:9][CH2:10][CH:11]2[CH2:12][CH2:13][CH:14]([C:17]3[CH:18]=[C:19]([F:25])[C:20]([F:24])=[C:21]([F:23])[CH:22]=3)[CH2:15][CH2:16]2)[O:26]1

Participants

5

Reactant 2

HCID 86748406HCID 86748406, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86748405HCID 86748405, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Pd/C (5% ) (1 g) was added to a solution of 1,1-ethylenedioxy -(2'-(4"-(3'",4'",5'"-trifluorophenyl)cyclohexyl)-ethyl)-3-cyclohexene (6.7 g) in ethanol (200 ml), followed by carrying out catalytic reduction in a hydrogen gas atmosphere, filtering off the catalyst after completion of the reaction and distilling off the solvent from the organic layer under reduced pressure, to obtain 1,1 -ethylenedioxy-(2'-(4"-(3'",4'",5'"-trifluorophenyl)cyclohexyl)ethyl)cyclohexane (6.2 g).

Workup

  1. filtrationfiltering off the catalyst
  2. customafter completion of the reaction
  3. distillationdistilling off the solvent from the organic layer under reduced pressure

Sources & evidence

ORD record
ord-6add5a1461c44a099eb7e1f9f6af1e88
Source dataset
uspto-grants-1995_01
Patent number
US05382379

Reaction notes

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