Morpholine → HCID 20097002, compound

HRID 1769592Notes

Reaction equation

HRID 1769592 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.CO[C:9]1[C:10]2[C:11](=[N:15][O:16][N+:17]=2[O-:18])[N:12]=[CH:13][N:14]=1>C(O)C>[O:4]1[CH2:5][CH2:6][N:1]([C:9]2[C:10]3[C:11](=[N:15][O:16][N+:17]=3[O-:18])[N:12]=[CH:13][N:14]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 3104939[1,2,5]Oxadiazolo[3,4-d]pyrimidine, 7-methoxy-, 1-oxide

Product 1

HCID 20097002HCID 20097002, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 1.6 g (18 mmol) of morpholine in 20 ml of ethanol is added to a mixture of 3.0 g (18 mmol) of 7-methoxy-[1,2,5]oxadiazolo[3,4-d]pyrimidine-1-oxide (Arzneim.-Forsch. 33 (1983) 803) and 100 ml of ethanol. After stirring at room temperature for 4 hours, the solvent is removed by distillation in vacuo and the residue is recrystallised from isopropanol. 3.6 g (90%) of 7-morpholino-[1,2,5]oxadiazolo[3,4-d]pyrimidine-1-oxide are obtained.

Workup

  1. customthe solvent is removed by distillation in vacuo
  2. customthe residue is recrystallised from isopropanol

Sources & evidence

ORD record
ord-003ff8d4aee740319ec7f458af54a9e6
Source dataset
uspto-grants-1995_01
Patent number
US05382585

Reaction notes

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