Morpholine → HCID 20097002, compound

Participants

Reaction Steps

A solution of 1.6 g (18 mmol) of morpholine in 20 ml of ethanol is added to a mixture of 3.0 g (18 mmol) of 7-methoxy-[1,2,5]oxadiazolo[3,4-d]pyrimidine-1-oxide (Arzneim.-Forsch. 33 (1983) 803) and 100 ml of ethanol. After stirring at room temperature for 4 hours, the solvent is removed by distillation in vacuo and the residue is recrystallised from isopropanol. 3.6 g (90%) of 7-morpholino-[1,2,5]oxadiazolo[3,4-d]pyrimidine-1-oxide are obtained.

Provenance & Evidence