Water → HCID 9947772, compound

HRID 1769614Notes

Reaction equation

HRID 1769614 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1.CO[CH:20]1[CH2:24][CH2:23][CH:22](OC)O1.O.[OH-].[Na+]>C(O)(=O)C>[N:17]1[CH:16]=[CH:15][CH:14]=[N:13][C:12]=1[N:9]1[CH2:8][CH2:7][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:1]2[CH:20]=[CH:24][CH:23]=[CH:22]2)[CH2:11][CH2:10]1

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 790982,5-DimethoxytetrahydrofuranHCID 128407054-(2-Pyrimidinyl)-1-piperazinebutanamine

Product 1

HCID 9947772HCID 9947772, compoundYield 45.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4 g (17 mmol) of 2-[4(4-aminobutyl)-1-piperazinyl]pyrimidine and 3.3 g of 2.5-dimethoxytetrahydrofuran in 10 ml of acetic acid is refluxed for 1 hour. The reaction mixture is poured into cold water, neutralised with 10% sodium hydroxide solution and extracted with chloroform, the extract is dried and evaporated and 2.2 g of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}pyrrole are obtained.

Workup

  1. temperatureis refluxed for 1 hour
  2. extractionextracted with chloroform
  3. customthe extract is dried
  4. customevaporated

Sources & evidence

ORD record
ord-159c80b33ba04119b88e5089d6b1ae1f
Source dataset
uspto-grants-1995_01
Patent number
US05382586

Reaction notes

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