HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 9947772, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| Reactant | 4-(2-Pyrimidinyl)-1-piperazinebutanamine | HCID 12840705 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 9947772 | HCID 9947772 | 45.3% |
Reaction Steps
A mixture of 4 g (17 mmol) of 2-[4(4-aminobutyl)-1-piperazinyl]pyrimidine and 3.3 g of 2.5-dimethoxytetrahydrofuran in 10 ml of acetic acid is refluxed for 1 hour. The reaction mixture is poured into cold water, neutralised with 10% sodium hydroxide solution and extracted with chloroform, the extract is dried and evaporated and 2.2 g of 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}pyrrole are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05382586 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-159c80b33ba04119b88e5089d6b1ae1f |
| Source note | uspto-grants-1995_01 |