Ammonia → HCID 15788034, compound

HRID 1769615Notes

Reaction equation

HRID 1769615 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]2)[CH2:9][CH2:8]1.N>Cl>[C:22]([C:20]1[CH:19]=[N:18][N:17]([CH2:16][CH2:15][CH2:14][CH2:13][N:10]2[CH2:11][CH2:12][N:7]([C:2]3[N:1]=[CH:6][CH:5]=[CH:4][N:3]=3)[CH2:8][CH2:9]2)[CH:21]=1)([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14726848HCID 14726848, compound

Product 1

HCID 15788034HCID 15788034, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 4.4 g (12.2 mmol) of ethyl 1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}-1H-pyrazole-4-carboxylate in 50 ml of 2N HCl is refluxed for 4 hours. The mixture is cooled in an ice bath, neutralised with ammonia and extracted with chloroform. 3.4 g of 4-carboxy-1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl}-1H-pyrazole with a melting point of 104°-105° C. are thus obtained.

Workup

  1. temperatureis refluxed for 4 hours
  2. temperatureThe mixture is cooled in an ice bath
  3. extractionextracted with chloroform

Sources & evidence

ORD record
ord-e8de513b641f48ca8d5bc783a1f70a73
Source dataset
uspto-grants-1995_01
Patent number
US05382586

Reaction notes

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