1-Phenylpiperazine → alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

HRID 1769621Notes

Reaction equation

HRID 1769621 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([OH:23])(=[O:22])[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH2:15]>C(O)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:13]([OH:23])=[O:22])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 68114Atropic acid

Product 1

HCID 19433570alpha-{[1-(4-Phenylpiperazinyl)]methyl}benzeneacetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Phenylpiperazine and atropic acid in ethanol is heated under reflux for 18 h, cooled to room temperature, and evaporated in vacuo. The solid is triturated with acetone to give the title product.

Workup

  1. temperatureunder reflux for 18 h
  2. customevaporated in vacuo
  3. customThe solid is triturated with acetone

Sources & evidence

ORD record
ord-961838b3deaa45069abb4e91321a9fdd
Source dataset
uspto-grants-1995_01
Patent number
US05382583

Reaction notes

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