m-Tolyl isocyanate → HCID 14996845, compound

HRID 1769689Notes

Reaction equation

HRID 1769689 reaction equation
[NH2:1][CH2:2][C:3]([N:5]([CH2:12][C:13]([N:15]([CH3:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:23][C:24]1[CH:25]=[C:26]([N:30]=[C:31]=[O:32])[CH:27]=[CH:28][CH:29]=1>>[CH3:22][N:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13](=[O:14])[CH2:12][N:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3](=[O:4])[CH2:2][NH:1][C:31]([NH:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH3:23])[CH:25]=1)=[O:32]

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 14996844HCID 14996844, compound

Product 1

HCID 14996845HCID 14996845, compoundYield 30.9%

Procedure

The procedure is analogous to that described in Example 1 but 0.9 g of 2-(2-amino-N-phenyl-acetamido)-N-methyl-N-phenylacetamide and 0.4 g of 3-methylphenyl isocyanate are used as the starting material. After recrystallization from a mixture of diethyl ether and ethyl acetate (60-40 by volume), 0.4 g of N-methyl-N-phenyl-2-{2-[3-(3-methylphenyl)ureido]-N-phenyl-acetamido}acetamide melting at 168° C. is obtained.

Workup

  1. customAfter recrystallization
  2. additionfrom a mixture of diethyl ether and ethyl acetate (60-40 by volume)

Sources & evidence

ORD record
ord-b938d3d7b96b4f6984bd9da5e50fb66a
Source dataset
uspto-grants-1995_01
Patent number
US05382590

Reaction notes

Loading…