反应详情

A solution of diisopropylamine (10.1 g, 0.1 mol) in dry ether (100 ml) was cooled to -10°. A solution of butyl lithium in hexane (65 ml, 0.1 mol) was added, and the mixture was stirred at -10° for 20 min. A solution of N-ethylidene-tert.butylamine (10 g, 0.1 mol) in dry ether (100 ml) was added and the solution was stirred at 0° for 20 min. After cooling to -30° a solution of 2,6-dimethoxybenzophenone (24.1 g, 0.1 mol) in dry ether (100 ml), containing 30 ml THF, was added. The mixture was then stirred at ambient temperature for 20 h and hydrolized with water. The organic phase was washed with water, dried and evaporated, giving 32 g (94%) of N-(3-(2,6-dimethoxyphenyl)-3-hydroxy-3phenylpropylidene)tert.butylamine as an oil.

1. stirringthe solution was stirred at 0° for 20 min
2. additionwas added
3. washThe organic phase was washed with water
4. customdried
5. customevaporated