4-Chlorophenol → HCID 20097343, compound

HRID 1769809Notes

Reaction equation

HRID 1769809 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[CH:5]=[CH:6][C:7]([OH:9])=[O:8].[Cl:14][C:15]1[CH:20]=[CH:19][C:18](O)=[CH:17][CH:16]=1>CC(C)=O>[Cl:14][C:15]1[CH:16]=[C:17]2[C:18](=[CH:19][CH:20]=1)[O:8][C:7](=[O:9])[CH2:6][CH:5]2[C:4]1[CH:10]=[CH:11][CH:12]=[CH:13][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 2

HCID 46844-ChlorophenolHCID 268622-Propenoic acid, 3-(methoxyphenyl)-

Product 1

HCID 20097343HCID 20097343, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6-Chloro-4-(2-methoxyphenyl)-3,4-dihydrocoumarin (CVII) was prepared in a similar way in 49% yield from 2-methoxycinnamic acid and p-chlorophenol, the reaction temperature being 130° in this case. M.p. 172°-173° (acetone).

Workup

  1. custombeing 130° in this case

Sources & evidence

ORD record
ord-3fd8fbed71234c7683c9aa0850a6bca9
Source dataset
uspto-grants-1995_01
Patent number
US05382600

Reaction notes

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