Monobasic potassium phosphate → Ribavirin

HRID 1769937Notes

Reaction equation

HRID 1769937 reaction equation
[NH:1]1C=CN=N1.[C@@H:6]1([N:15]2C3N=C[N:21]=[C:19]([OH:20])[C:18]=3[N:17]=[CH:16]2)[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]1[OH:8].P([O-])(O)(O)=O.[K+]>>[CH:16]1[N:15]([C@@H:6]2[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]2[OH:8])[N:1]=[C:18]([C:19]([NH2:21])=[O:20])[N:17]=1

Participants

4

Reactant 3

HCID 516951Monobasic potassium phosphateHCID 178418936HCID 178418936, compoundHCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

Product 1

HCID 37542Ribavirin

Procedure

By using a substrate solution (pH 6.0) containing 40 mM triazole as the base donor, 60 mM inosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, reactions were carried out in the same manner as in Example 1 at respective reaction temperature (40° to 70° C.) for 24 hours to produce ribavirin. The results are shown in Table 8.

Sources & evidence

ORD record
ord-6a291c8c92784860a8195839aa28a1c9
Source dataset
uspto-grants-1995_01
Patent number
US05384251

Reaction notes

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