反应详情

To a stirred solution of 1-(4-formylphenyl)pyrrolidine (1.5 g) in MeOH (50 ml) was added hydroxylamine hydrochloride (0.62 g) and pyridine (0.70 g). The mixture was stirred for 2 hours at room temperature and the solvent was removed under reduced pressure. The resulting crystals were washed with Et2O. Without further purification, a stirred solution of the product (1.03 g) in acetic acid (20 ml) was treated with NaBH3CN (0.34 g) by portions at room temperature. The mixture was stirred for 3 hours then H2O was added. The reaction mixture was cooled to 0° C. and aqueous NaOH solution was added until the mixture was basic. The resulting mixture was extracted with CH2Cl2 and washed with saturated NaCl solution. The extract was dried over MgSO4 and concentrated in vacuo. Without further purification, the crude product (1.01 g) was dissolved in dry THF (22 ml). The THF solution was stirred and trimethylsilylisocyanate (1.5 ml) was added at room temperature. The mixture was stirred for 1 hour and the solvent was removed under reduced pressure. The precipitate was purified by recrystallization from EtOH, yielding the title compound (0.40 g), m.p. 127.5°-128° C. (dec.).

1. customthe solvent was removed under reduced pressure
2. washThe resulting crystals were washed with Et2O
3. customWithout further purification
4. additiona stirred solution of the product (1.03 g) in acetic acid (20 ml) was treated with NaBH3CN (0.34 g) by portions at room temperature
5. stirringThe mixture was stirred for 3 hours
6. additionH2O was added
7. temperatureThe reaction mixture was cooled to 0° C.
8. additionaqueous NaOH solution was added until the mixture
9. extractionThe resulting mixture was extracted with CH2Cl2
10. washwashed with saturated NaCl solution
11. dry with materialThe extract was dried over MgSO4
12. concentrationconcentrated in vacuo
13. customWithout further purification
14. dissolutionthe crude product (1.01 g) was dissolved in dry THF (22 ml)
15. stirringThe THF solution was stirred
16. additiontrimethylsilylisocyanate (1.5 ml) was added at room temperature
17. stirringThe mixture was stirred for 1 hour
18. customthe solvent was removed under reduced pressure
19. customThe precipitate was purified by recrystallization from EtOH