Hydrochloric Acid → HCID 178524033, compound

HRID 1770078Notes

Reaction equation

HRID 1770078 reaction equation
Br[C:2]1[N:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[C:3]=1[C:4]([OH:6])=[O:5].NC(N)=[S:20].Cl.[OH-].[Na+]>O.C(O)(=O)C>[SH:20][C:2]1[N:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[C:3]=1[C:4]([OH:6])=[O:5]

Participants

7

Reactant 4

HCID 313Hydrochloric Acid2×HCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 157671372-Bromo-4-(4-chloro-phenyl)-nicotinic acid

Product 1

HCID 178524033HCID 178524033, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

73.9 g (0.24 mol) of 2-bromo-4-(4-clorophenyl)nicotinic acid and 22.0 g (0.29 mol) of thiourea were weighed, and 100 ml of 5% HCl aqueous solution and 150 ml of acetic acid were added thereto. The resultant mixture was stirred at 100° C. for 2 hours, and was poured into water. Thereafter, 400 ml of 50% sodium hydroxide aqueous solution was added to the resultant mixture, and the mixture was stirred at room temperature for 30 minutes. The mixture was then acidified with 20% HCl aqueous solution, and the crystal thus precipitated was filtrated out and was washed with water. The washed crystal was then dried to obtain a crude crystal of 2-mercapto-4-(4-chlorophenyl)nicotinic acid.

Workup

  1. customthe crystal thus precipitated
  2. filtrationwas filtrated out and
  3. washwas washed with water
  4. customThe washed crystal was then dried

Sources & evidence

ORD record
ord-59d1de807e3d483d95899310fb4fec26
Source dataset
uspto-grants-1995_01
Patent number
US05385880

Reaction notes

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