Hydrochloric Acid → (2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride

HRID 1770115노트

반응식

HRID 1770115 반응식
[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9](C(=O)C)[CH2:8][CH2:7]1)=[O:5].[ClH:20]>C(O)(=O)C>[ClH:20].[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[C:4]([CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)=[O:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

생성물 1

HCID 18759874(2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride수율 83%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The preceding ketone (40 g, 0.15 mol) was added to a mixture of 125 ml concentrated HCl and 125 ml acetic acid and refluxed for 16 hours, cooled, and concentrated in vacuo. The white residue was triturated with hot isopropanol, filtered, washed with Et2O and dried to give 32.3 g (83%) of 4-(2,4-difluorobenzoyl)piperidine hydrochloride (III), m.p. 215°-216° C.

후처리

  1. temperaturerefluxed for 16 hours
  2. temperaturecooled
  3. concentrationconcentrated in vacuo
  4. customThe white residue was triturated with hot isopropanol
  5. filtrationfiltered
  6. washwashed with Et2O
  7. customdried

출처 및 근거

ORD 기록
ord-7df330dd9e3743f7861f830d03c91367
출처 데이터셋
uspto-grants-1995_01
특허 번호
US05385916

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