反应详情

The preceding ketone (40 g, 0.15 mol) was added to a mixture of 125 ml concentrated HCl and 125 ml acetic acid and refluxed for 16 hours, cooled, and concentrated in vacuo. The white residue was triturated with hot isopropanol, filtered, washed with Et2O and dried to give 32.3 g (83%) of 4-(2,4-difluorobenzoyl)piperidine hydrochloride (III), m.p. 215°-216° C.

1. temperaturerefluxed for 16 hours
2. temperaturecooled
3. concentrationconcentrated in vacuo
4. customThe white residue was triturated with hot isopropanol
5. filtrationfiltered
6. washwashed with Et2O
7. customdried