Phenyl Isothiocyanate → HCID 15157810, compound

HRID 1770138Notes

Reaction equation

HRID 1770138 reaction equation
[CH3:1][NH:2][CH2:3][CH:4]([OH:18])[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2.[C:19]1([N:25]=[C:26]=[S:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[CH3:1][N:2]([CH2:3][CH:4]([OH:18])[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2)[C:26]([NH:25][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[S:27]

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 10106057HCID 10106057, compound

Product 1

HCID 15157810HCID 15157810, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 6-(3-methylamino-2-hydroxypropoxy)carbostyril (0.7 g) in ethanol (10 ml) is added phenylisothiocyanate (0.35 ml) at room temperature, and the mixture is stirred at the same temperature for 1 hour. The insoluble product is collected by filtration and recrystallized from chloroform-methanol to give 6-[3-(1-methyl-3-phenylthioureido)-2-hydroxypropoxy]carbostyril (0.83 g), as white powder, m.p. 185.0°-186.5° C. (decomp.).

Workup

  1. filtrationThe insoluble product is collected by filtration
  2. customrecrystallized from chloroform-methanol

Sources & evidence

ORD record
ord-89e57c3366014c698e7effe05d7b11fc
Source dataset
uspto-grants-1995_01
Patent number
US05385914

Reaction notes

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