Benzene → HCID 67623507, compound

HRID 1770161Notes

Reaction equation

HRID 1770161 reaction equation
[CH2:1]([CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]([NH:20][CH2:21][C:22]([OH:24])=[O:23])=O)[CH:15]=2)[CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C1C=CC=CC=1>C(N(CC)CC)C>[CH2:1]([CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH:18]3[N:20]=[CH:21][C:22](=[O:23])[O:24]3)[CH:15]=2)[CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 241BenzeneHCID 20095021HCID 20095021, compound

Product 1

HCID 67623507HCID 67623507, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Subsequently, 1.55 g (4.68 mM) of N-(2-octylindan-5-carbonyl)glycine and 25 ml of dry benzene were placed in a 50 ml-three necked flask. Under stirring at room temperature, 0.66 ml (4.74 mM) of triethylamine and 0.46 ml (4.81 mM) were successively added to the above mixture, followed by further stirring for 23 minutes at room temperature to precipitate a crystal. After the reaction, the precipitated triethylamine hydrochloride was removed by filtration and the filtrate was evaporated under reduced pressure to obtain a residue. The residue was dried under reduced pressure to obtain 2-(2-octylindan-5-yl)-5-oxazolone.

Workup

  1. stirringby further stirring for 23 minutes at room temperature
  2. customto precipitate a crystal
  3. customAfter the reaction
  4. customthe precipitated triethylamine hydrochloride was removed by filtration
  5. customthe filtrate was evaporated under reduced pressure
  6. customto obtain a residue
  7. customThe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-41d5a29d58604464bfd6bed6234c129c
Source dataset
uspto-grants-1995_01
Patent number
US05385692

Reaction notes

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