Ammonia → 2-(7-Methoxynaphthalen-1-yl)acetamide

HRID 1770229Notes

Reaction equation

HRID 1770229 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14](Cl)=[O:15])=[CH:5][CH:4]=1.[NH3:17]>CCOCC>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([NH2:17])=[O:15])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 193857662-(7-Methoxynaphthalen-1-yl)acetyl chloride

Product 1

HCID 151491272-(7-Methoxynaphthalen-1-yl)acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The (7-methoxynaphth-1-yl)acetyl chloride obtained above is dissolved in 200 cm3 of anhydrous ether. After cooling the solution with the aid of an ice-salt bath, 200 cm3 of an aqueous concentrated ammonia solution are added, with stirring. The mixture is stirred for 30 minutes, and the resulting precipitate is suction filtered. The product is recrystallised in ethanol.

Workup

  1. temperatureAfter cooling the solution with the aid of an ice-salt bath
  2. stirringThe mixture is stirred for 30 minutes
  3. filtrationfiltered
  4. customThe product is recrystallised in ethanol

Sources & evidence

ORD record
ord-960ed8bd9d964c99865740ac5ff6b9c6
Source dataset
uspto-grants-1995_01
Patent number
US05385944

Reaction notes

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