Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → HCID 53375153, compound

HRID 1770615Notes

Reaction equation

HRID 1770615 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:12]=[C:11]([N:13]3[C:17](=[O:18])[C:16]([CH3:20])([CH3:19])[NH:15][C:14]3=[O:21])[CH:10]=[N:9]2)=[C:5]([CH3:22])[O:4][N:3]=1.Cl[CH2:24][C:25]1[C:26]([CH3:31])=[N:27][O:28][C:29]=1[CH3:30]>>[CH3:31][C:26]1[C:25]([CH2:24][N:15]2[C:16]([CH3:19])([CH3:20])[C:17](=[O:18])[N:13]([C:11]3[CH:10]=[N:9][N:8]([CH2:7][C:6]4[C:2]([CH3:1])=[N:3][O:4][C:5]=4[CH3:22])[CH:12]=3)[C:14]2=[O:21])=[C:29]([CH3:30])[O:28][N:27]=1

Participants

3

Reactant 2

HCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-HCID 595243883-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione

Product 1

HCID 53375153HCID 53375153, compound

Procedure

Prepared as in Example 12-16 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione (Example 12-16a) and 4-(chloromethyl)-3,5-dimethylisoxazole. MS 413 (MH+). The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.08 μM.

Sources & evidence

ORD record
ord-4ca8e9aa6a8448268e9a4aafba284a6b
Source dataset
uspto-grants-2016_02
Patent number
US09247759B2

Reaction notes

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