Pyroglutamate → (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine pyroglutamate salt

HRID 1770674Notes

Reaction equation

[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](O)=[O:6].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[CH2:21][CH2:20][NH:19][CH2:18][C@H:17]([CH3:22])[C:16]=2[CH:23]=1.N1C(=O)CC[C@H]1C([O-])=O>>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:8]([OH:10])=[O:9].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[CH2:21][CH2:20][NH:19][CH2:18][C@H:17]([CH3:22])[C:16]=2[CH:23]=1

Participants

Reactant 2

HCID 5289118Pyroglutamate

HCID 56929575HCID 56929575, compound

Product 1

HCID 86702388(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine pyroglutamate salt

Procedure

The aqueous solubility of Compound 1 pyroglutamate was determined to be >161.5 mg/mL at pH 3.94.

Sources & evidence

ORD record: ord-dcba436418164a518817851e06e91f94
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09248133B2

Reaction notes

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