Water → Benzyl 4-mercapto-2-methylbutan-2-ylcarbamate

関与物質

反応手順

To a solution of S-3-(benzyloxycarbonylamino)-3-methylbutyl ethanethioate (1.52 g, 5.14 mmol, prepared as described in WO 2008/083347) in methanol (25 ml) was added 5.0 M NaOH in H2O (3.3 ml, 16.5 mmol). The solution was stirred for 1 hour, concentrated in vacuo, and the residue suspended in 100 ml 1M H3PO4, extracted with 5×50 ml ethyl acetate, the organic layers combined and washed once with 100 ml saturated NaCl, dried on MgSO4, and concentrated in vacuo. The reaction product was used in the next step without further purification.

情報源と証拠