反应详情

To a solution of S-3-(benzyloxycarbonylamino)-3-methylbutyl ethanethioate (1.52 g, 5.14 mmol, prepared as described in WO 2008/083347) in methanol (25 ml) was added 5.0 M NaOH in H2O (3.3 ml, 16.5 mmol). The solution was stirred for 1 hour, concentrated in vacuo, and the residue suspended in 100 ml 1M H3PO4, extracted with 5×50 ml ethyl acetate, the organic layers combined and washed once with 100 ml saturated NaCl, dried on MgSO4, and concentrated in vacuo. The reaction product was used in the next step without further purification.

1. concentrationconcentrated in vacuo
2. extractionextracted with 5×50 ml ethyl acetate
3. washwashed once with 100 ml saturated NaCl
4. customdried on MgSO4
5. concentrationconcentrated in vacuo
6. customThe reaction product was used in the next step without further purification