HCID 67507979, compound → HCID 86665512, compound

HRID 1770682Notes

Reaction equation

HRID 1770682 reaction equation
[OH:1][CH2:2][CH2:3][S:4]([CH2:7][CH2:8][C:9]([NH:12]C(=O)OCC1C=CC=CC=1)([CH3:11])[CH3:10])(=[O:6])=[O:5].[H][H]>CO.[Pd]>[NH2:12][C:9]([CH3:11])([CH3:10])[CH2:8][CH2:7][S:4]([CH2:3][CH2:2][OH:1])(=[O:6])=[O:5]

Participants

5

Reactant 2

HCID 67507979HCID 67507979, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86665512HCID 86665512, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of benzyl 4-(2-hydroxyethylsulfonyl)-2-methylbutan-2-ylcarbamate (790 mg, 2.40 mmol) in methanol (30 ml) was purged with nitrogen and palladium on carbon (10%, 120 mg) was added. The solution was put under a blanket of hydrogen (1.3 atmospheres) and stirred for 1.5 hours at room temperature. The suspension was filtered through 0.45 um PTFE and concentrated in vacuo to afford the title compound which was used without further purification. LRMS (ESI/APCI) m/z 196 [M+H]+.

Workup

  1. additionwas added
  2. filtrationThe suspension was filtered through 0.45 um PTFE
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-47be4f667b43495c88a1700096d3a7ee
Source dataset
uspto-grants-2016_02
Patent number
US09248117B2

Reaction notes

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